Elevated γ‐aminobutyric acid level in striatal but not extrastriatal brain regions in Parkinson's disease: Correlation with striatal dopamine loss
Identifieur interne : 004E74 ( Main/Exploration ); précédent : 004E73; suivant : 004E75Elevated γ‐aminobutyric acid level in striatal but not extrastriatal brain regions in Parkinson's disease: Correlation with striatal dopamine loss
Auteurs : Mary E. Kish [Canada] ; Ali Rajput [Canada] ; Joseph Gilbert [Canada] ; Bohdan Rozdilsky [Canada] ; Li-Jan Chang [Canada] ; Kathleen Shannak [Canada] ; Oleh Hornykiewicz [Canada, Autriche]Source :
- Annals of Neurology [ 0364-5134 ] ; 1986-07.
Abstract
We measured the concentration of γ‐aminobutyric acid (GABA), glutamic acid, and o‐phosphoethanolamine in autopsied brain of 9 patients who died with idiopathic Parkinson's disease and 10 control subjects. In the control striatum GABA showed an uneven rostrocaudal distribution pattern with rostral subdivisions containing about 40 to 50% higher levels. When compared with controls, GABA concentrations in Parkinson's disease striatum were generally elevated. The GABA elevation was most pronounced in the caudal subdivision of the putamen; this striatal subdivision also showed the most severe dopamine loss. We observed in the caudal putamen a significant negative correlation between the (elevated) GABA and (reduced) dopamine levels (the latter expressed as the sum of dopamine plus 3‐methoxytyramine). Milder nonsignificant elevations of GABA levels were observed in intermediate and rostral putamen followed by the caudate head subdivisions. GABA levels were normal in all extrastriatal brain areas examined. Striatal glutamic acid levels were markedly elevated in 3 of the 9 patients with Parkinson's disease. We suggest that the altered GABA metabolism in the striatum, especially the putamen, is consequent to the nigrostriatal deficiency in this disorder. This secondary change in striatal GABA function is likely to contribute to the basal ganglia dysfunction produced by the striatal dopamine loss and thus may be related to certain aspects of parkinsonian symptomatology.
Url:
DOI: 10.1002/ana.410200106
Affiliations:
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In the control striatum GABA showed an uneven rostrocaudal distribution pattern with rostral subdivisions containing about 40 to 50% higher levels. When compared with controls, GABA concentrations in Parkinson's disease striatum were generally elevated. The GABA elevation was most pronounced in the caudal subdivision of the putamen; this striatal subdivision also showed the most severe dopamine loss. We observed in the caudal putamen a significant negative correlation between the (elevated) GABA and (reduced) dopamine levels (the latter expressed as the sum of dopamine plus 3‐methoxytyramine). Milder nonsignificant elevations of GABA levels were observed in intermediate and rostral putamen followed by the caudate head subdivisions. GABA levels were normal in all extrastriatal brain areas examined. Striatal glutamic acid levels were markedly elevated in 3 of the 9 patients with Parkinson's disease. We suggest that the altered GABA metabolism in the striatum, especially the putamen, is consequent to the nigrostriatal deficiency in this disorder. This secondary change in striatal GABA function is likely to contribute to the basal ganglia dysfunction produced by the striatal dopamine loss and thus may be related to certain aspects of parkinsonian symptomatology.</div></front></TEI><affiliations><list><country><li>Autriche</li><li>Canada</li></country><region><li>Ontario</li><li>Vienne (Autriche)</li></region><settlement><li>Vienne (Autriche)</li></settlement></list><tree><country name="Canada"><region name="Ontario"><name sortKey="Kish, Mary E" sort="Kish, Mary E" uniqKey="Kish M" first="Mary E." last="Kish">Mary E. Kish</name></region><name sortKey="Chang, Li An" sort="Chang, Li An" uniqKey="Chang L" first="Li-Jan" last="Chang">Li-Jan Chang</name><name sortKey="Gilbert, Joseph" sort="Gilbert, Joseph" uniqKey="Gilbert J" first="Joseph" last="Gilbert">Joseph Gilbert</name><name sortKey="Hornykiewicz, Oleh" sort="Hornykiewicz, Oleh" uniqKey="Hornykiewicz O" first="Oleh" last="Hornykiewicz">Oleh Hornykiewicz</name><name sortKey="Rajput, Ali" sort="Rajput, Ali" uniqKey="Rajput A" first="Ali" last="Rajput">Ali Rajput</name><name sortKey="Rozdilsky, Bohdan" sort="Rozdilsky, Bohdan" uniqKey="Rozdilsky B" first="Bohdan" last="Rozdilsky">Bohdan Rozdilsky</name><name sortKey="Shannak, Kathleen" sort="Shannak, Kathleen" uniqKey="Shannak K" first="Kathleen" last="Shannak">Kathleen Shannak</name></country><country name="Autriche"><region name="Vienne (Autriche)"><name sortKey="Hornykiewicz, Oleh" sort="Hornykiewicz, Oleh" uniqKey="Hornykiewicz O" first="Oleh" last="Hornykiewicz">Oleh Hornykiewicz</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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